Roland Zemla

I am interested in understanding how the entorhinal cortex supports encoding and recall of contextually variant spatial maps in hippocampus. To investigate this, I use in vivo 2-photon microscopy to image hippocampal activity across time during a context-dependent navigation task while perturbing entorhinal function with next-generation chemogenetic tools. I hope to gain insight into the neural mechanism of cognitive decline associated with neurodegenerative disease such as Alzheimer’s in which dysfunction of the entorhinal cortex is an early hallmark of the disease.